The Implications of PDK1–4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance

The Implications of PDK1–4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance

A metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis—known as the Warburg effect—is characteristic for many cancers. It gives the cancer cells a survival advantage in the hypoxic tumor microenvironment and protects them from cytotoxic effects of oxidative damage and apoptosis. The...

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Bibliographic Details
Main Authors: Emine Atas, Monika Oberhuber, Lukas Kenner
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
pyruvate dehydrogenase kinase
tricarboxylic acid cycle
oxidative phosphorylation
Warburg effect
aerobic glycolysis
prostate cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.583217/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.583217/full

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