The Implications of PDK1–4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance
A metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis—known as the Warburg effect—is characteristic for many cancers. It gives the cancer cells a survival advantage in the hypoxic tumor microenvironment and protects them from cytotoxic effects of oxidative damage and apoptosis. The...
Main Authors: | Emine Atas, Monika Oberhuber, Lukas Kenner |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-12-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.583217/full |
Similar Items
-
Huzhangoside A Suppresses Tumor Growth through Inhibition of Pyruvate Dehydrogenase Kinase Activity
by: Choong-Hwan Kwak, et al.
Published: (2019-05-01) -
Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity
by: Choong-Hwan Kwak, et al.
Published: (2020-08-01) -
Pyruvate dehydrogenase kinase inhibition: Reversing the Warburg effect in cancer therapy
by: Hayden Bell, et al.
Published: (2016-06-01) -
PKM2, function and expression and regulation
by: Ze Zhang, et al.
Published: (2019-06-01) -
Melatonin Therapy Modulates Cerebral Metabolism and Enhances Remyelination by Increasing PDK4 in a Mouse Model of Multiple Sclerosis
by: Majid Ghareghani, et al.
Published: (2019-02-01)