Hexosamine Biosynthetic Pathway-Derived O-GlcNAcylation Is Critical for RANKL-Mediated Osteoclast Differentiation

Hexosamine Biosynthetic Pathway-Derived O-GlcNAcylation Is Critical for RANKL-Mediated Osteoclast Differentiation

O-linked-N-acetylglucosaminylation (O-GlcNAcylation) performed by O-GlcNAc transferase (OGT) is a nutrient-responsive post-translational modification (PTM) via the hexosamine biosynthetic pathway (HBP). Various transcription factors (TFs) are O-GlcNAcylated, affecting their activities and significan...

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Bibliographic Details
Main Authors: Myoung Jun Kim, Hyuk Soon Kim, Sangyong Lee, Keun Young Min, Wahn Soo Choi, Jueng Soo You
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
O-GlcNAc transferase
O-GlcNAcylation
osteoclastogenesis
osteoclast
NFATc1
p65
Online Access:https://www.mdpi.com/1422-0067/22/16/8888

Internet

https://www.mdpi.com/1422-0067/22/16/8888

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