Docetaxel-Loaded Self-Assembly Stearic Acid-Modified Bletilla striata Polysaccharide Micelles and Their Anticancer Effect: Preparation, Characterization, Cellular Uptake and In Vitro Evaluation

Docetaxel-Loaded Self-Assembly Stearic Acid-Modified Bletilla striata Polysaccharide Micelles and Their Anticancer Effect: Preparation, Characterization, Cellular Uptake and In Vitro Evaluation

Poorly soluble drugs have low bioavailability after oral administration, thereby hindering effective drug delivery. A novel drug-delivery system of docetaxel (DTX)-based stearic acid (SA)-modified Bletilla striata polysaccharides (BSPs) copolymers was successfully developed. Particle size, zeta pote...

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Bibliographic Details
Main Authors: Qingxiang Guan, Dandan Sun, Guangyuan Zhang, Cheng Sun, Miao Wang, Danyang Ji, Wei Yang
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Molecules
Subjects:
docetaxel
Bletilla striata polysaccharide
copolymer micelle
hemolysis assay
anticancer activity
apoptotic
Online Access:http://www.mdpi.com/1420-3049/21/12/1641

Internet

http://www.mdpi.com/1420-3049/21/12/1641

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