Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis
Clozapine is an efficacious atypical antipsychotic for treatment-refractory schizophrenia. Clinical response and appearance of adverse events vary among individual patients receiving clozapine, with genetic and non-genetic factors potentially contributing to individual variabilities. Pharmacogenetic...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-09-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01049/full |
id |
doaj-f74f97c9a41146afb779646b10577e95 |
---|---|
record_format |
Article |
spelling |
doaj-f74f97c9a41146afb779646b10577e952020-11-25T01:17:21ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-09-01910.3389/fphar.2018.01049407239Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and AgranulocytosisShusuke Numata0Hidehiro Umehara1Tetsuro Ohmori2Ryota Hashimoto3Ryota Hashimoto4Ryota Hashimoto5Department of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, JapanDepartment of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, JapanDepartment of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, JapanDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, JapanMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, JapanDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanClozapine is an efficacious atypical antipsychotic for treatment-refractory schizophrenia. Clinical response and appearance of adverse events vary among individual patients receiving clozapine, with genetic and non-genetic factors potentially contributing to individual variabilities. Pharmacogenetic studies investigate associations between genetic variants and drug efficacy and toxicity. To date, most pharmacogenetic studies of clozapine have been conducted through candidate gene approaches. A recent advance in technology made it possible to perform comprehensive genetic mapping underlying clinical phenotypes and outcomes, which allow novel findings beyond biological hypotheses based on current knowledge. In this paper, we will summarize the studies on clozapine pharmacogenetics that have extensively examined clinical response and agranulocytosis. While there is still limited evidence on clozapine efficacy, recent genome-wide studies provide further evidence of the involvement of the human leukocyte antigen (HLA) region in clozapine-induced agranulocytosis.https://www.frontiersin.org/article/10.3389/fphar.2018.01049/fullclozapineschizophreniaclinical responseagranulocytosispharmacogeneticsSNP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shusuke Numata Hidehiro Umehara Tetsuro Ohmori Ryota Hashimoto Ryota Hashimoto Ryota Hashimoto |
spellingShingle |
Shusuke Numata Hidehiro Umehara Tetsuro Ohmori Ryota Hashimoto Ryota Hashimoto Ryota Hashimoto Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis Frontiers in Pharmacology clozapine schizophrenia clinical response agranulocytosis pharmacogenetics SNP |
author_facet |
Shusuke Numata Hidehiro Umehara Tetsuro Ohmori Ryota Hashimoto Ryota Hashimoto Ryota Hashimoto |
author_sort |
Shusuke Numata |
title |
Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis |
title_short |
Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis |
title_full |
Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis |
title_fullStr |
Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis |
title_full_unstemmed |
Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis |
title_sort |
clozapine pharmacogenetic studies in schizophrenia: efficacy and agranulocytosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2018-09-01 |
description |
Clozapine is an efficacious atypical antipsychotic for treatment-refractory schizophrenia. Clinical response and appearance of adverse events vary among individual patients receiving clozapine, with genetic and non-genetic factors potentially contributing to individual variabilities. Pharmacogenetic studies investigate associations between genetic variants and drug efficacy and toxicity. To date, most pharmacogenetic studies of clozapine have been conducted through candidate gene approaches. A recent advance in technology made it possible to perform comprehensive genetic mapping underlying clinical phenotypes and outcomes, which allow novel findings beyond biological hypotheses based on current knowledge. In this paper, we will summarize the studies on clozapine pharmacogenetics that have extensively examined clinical response and agranulocytosis. While there is still limited evidence on clozapine efficacy, recent genome-wide studies provide further evidence of the involvement of the human leukocyte antigen (HLA) region in clozapine-induced agranulocytosis. |
topic |
clozapine schizophrenia clinical response agranulocytosis pharmacogenetics SNP |
url |
https://www.frontiersin.org/article/10.3389/fphar.2018.01049/full |
work_keys_str_mv |
AT shusukenumata clozapinepharmacogeneticstudiesinschizophreniaefficacyandagranulocytosis AT hidehiroumehara clozapinepharmacogeneticstudiesinschizophreniaefficacyandagranulocytosis AT tetsuroohmori clozapinepharmacogeneticstudiesinschizophreniaefficacyandagranulocytosis AT ryotahashimoto clozapinepharmacogeneticstudiesinschizophreniaefficacyandagranulocytosis AT ryotahashimoto clozapinepharmacogeneticstudiesinschizophreniaefficacyandagranulocytosis AT ryotahashimoto clozapinepharmacogeneticstudiesinschizophreniaefficacyandagranulocytosis |
_version_ |
1725146325442363392 |