G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity

G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity

Alzheimer's disease is characterized by cognitive decline, neuronal degeneration, and the accumulation of amyloid-beta (Aβ). Although, the neurotoxic Aβ peptide is widely believed to trigger neuronal dysfunction and degeneration in Alzheimer's disease, the mechanism by which this occurs is...

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Bibliographic Details
Main Authors: Linda M. May, Victor Anggono, Helen M. Gooch, Se E. Jang, Dusan Matusica, Georg M. Kerbler, Frederic A. Meunier, Pankaj Sah, Elizabeth J. Coulson
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Neuroscience
Subjects:
p75NTR
amyloid β
Alzheimer's disease
neurodegeneration
excitotoxicity
potassium flux
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00455/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00455/full

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