Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS

Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS

Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and renal failure. It is caused by genetic or acquired defects of the complement alternative pathway. Factor H autoantibodies (anti-FHs) have been reported in 10% of aHUS...

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Main Authors: Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Rossella Piras, Caterina Mele, Matteo Breno, Alessandra Cremaschi, Elena Bresin, Roberta Donadelli, Silvia Alizzi, Antonio Amoroso, Ariela Benigni, Giuseppe Remuzzi, Marina Noris
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
autoantibodies
atypical hemolytic uremic syndrome
factor H
factor H related 1
complement
genetic variants
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00853/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00853/full

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