Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells

Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells

Ex vivo hematopoietic stem and progenitor cell (HSPC) expansion platforms are under active development, designed to increase HSPC numbers and thus engraftment ability of allogeneic cord blood grafts or autologous HSPCs for gene therapies. Murine and in vitro models have not correlated well with clin...

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Bibliographic Details
Main Authors: Sandeep K. Srivastava, Lauren L. Truitt, Chuanfeng Wu, Adam Glaser, Daniel J. Nolan, Michael Ginsberg, Diego A. Espinoza, Samson Koelle, Idalia M. Yabe, Kyung-Rok Yu, Sogun Hong, Stephanie Sellers, Allen Krouse, Aylin Bonifacino, Mark Metzger, Pradeep K. Dagur, Robert E. Donahue, Cynthia E. Dunbar, Sandhya R. Panch
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
hematopoiesis
ex-vivo expansion
HUVECs
rhesus macaque
genetic barcoding
clonal expansion
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000243

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http://www.sciencedirect.com/science/article/pii/S2329050121000243

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