Synthesis of a library of tricyclic azepinoisoindolinones

Synthesis of a library of tricyclic azepinoisoindolinones

Hydrozirconation of 1-hexyne, the addition to in situ prepared N-acyliminium species, and ring-closing metathesis (RCM) were key steps in the preparation of a tricyclic isoindolinone scaffold. An unusual alkene isomerization process during the RCM was identified and studied in some detail. Chemical...

Full description

Bibliographic Details
Main Authors: Bettina Miller, Shuli Mao, Kara M. George Rosenker, Joshua G. Pierce, Peter Wipf
Format: Article
Language:English
Published: Beilstein-Institut 2012-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chemical diversity
epoxide aminolysis
hydrozirconation
isoindolinones
metathesis
N-acyliminium ion
Online Access:https://doi.org/10.3762/bjoc.8.120

Internet

https://doi.org/10.3762/bjoc.8.120

Similar Items