Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.

Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.

Age-associated thymic involution has considerable physiological impact by inhibiting de novo T-cell selection. This impaired T-cell production leads to weakened immune responses. Yet the molecular mechanisms of thymic stromal adipose involution are not clear. Age-related alterations also occur in th...

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Bibliographic Details
Main Authors: Krisztian Kvell, Zoltan Varecza, Domokos Bartis, Sebastian Hesse, Sonia Parnell, Graham Anderson, Eric J Jenkinson, Judit E Pongracz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2872673?pdf=render

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http://europepmc.org/articles/PMC2872673?pdf=render

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