Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions.

Mutations in amyloid precursor protein (APP) have been most intensely studied in brain tissue for their link to Alzheimer's disease (AD) pathology. However, APP is highly expressed in a variety of tissues including adipose tissue, where APP is also known to exhibit increased expression in respo...

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Bibliographic Details
Main Authors: Linnea R Freeman, Le Zhang, Kalavathi Dasuri, Sun-Ok Fernandez-Kim, Annadora J Bruce-Keller, Jeffrey N Keller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3422309?pdf=render