Glucagon-Like Peptide-1 Receptor Agonist Attenuates Autophagy to Ameliorate Pulmonary Arterial Hypertension through Drp1/NOX- and Atg-5/Atg-7/Beclin-1/LC3β Pathways

Glucagon-Like Peptide-1 Receptor Agonist Attenuates Autophagy to Ameliorate Pulmonary Arterial Hypertension through Drp1/NOX- and Atg-5/Atg-7/Beclin-1/LC3β Pathways

Mitochondrial dysfunction is associated with cardiovascular diseases and diabetes. Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling, and the abnormal proliferation, apoptosis and migration of pulmonary arterial smooth muscle cells (PASMCs). The glucagon-like pe...

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Bibliographic Details
Main Authors: Yi-Chia Wu, Wei-Ting Wang, Su-Shin Lee, Yur-Ren Kuo, Ya-Chin Wang, Shih-Jung Yen, Mei-Yueh Lee, Jwu-Lai Yeh
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
GLP-1 receptor agonists
liraglutide
pulmonary artery hypertension
autophagy
mitochondria
Online Access:https://www.mdpi.com/1422-0067/20/14/3435

Internet

https://www.mdpi.com/1422-0067/20/14/3435

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