Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives

Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives

Apela (also known as Elabela, Ende, and Toddler) is a small signaling peptide that activates the G-protein-coupled receptor Aplnr to stimulate cell migration during zebrafish gastrulation. Here, using CRISPR/Cas9 to generate a null, reporter-expressing allele, we study the role of Apela in the devel...

Full description

Bibliographic Details
Main Authors: Laina Freyer, Chih-Wei Hsu, Sonja Nowotschin, Andrea Pauli, Junji Ishida, Keiji Kuba, Akiyoshi Fukamizu, Alexander F. Schier, Pamela A. Hoodless, Mary E. Dickinson, Anna-Katerina Hadjantonakis
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
Apela
Elabela
Ende
Toddler
Aplnr
APJ
Apelin
gastrulation
cardiovascular development
micro-computed tomography
microCT
macrophages
vascular remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311063

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717311063

Similar Items