Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for Inhibitor Specificity

Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for Inhibitor Specificity

Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential drug targets for the treatment of cancer and other pathologies. We screened the activation loop mutant kinases hNek1 and hNek2, wild-type hNek7, and five hNek6 variants i...

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Bibliographic Details
Main Authors: Eduardo Cruz Moraes, Gabriela Vaz Meirelles, Rodrigo Vargas Honorato, Tatiana de Arruda Campos Brasil de Souza, Edmarcia Elisa de Souza, Mario Tyago Murakami, Paulo Sergio Lopes de Oliveira, Jörg Kobarg
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
drug discovery
compound screening
kinase assays
molecular modeling
molecular docking
ATP-competitive inhibitors
non-competitive inhibition
Neks
Online Access:http://www.mdpi.com/1420-3049/20/1/1176

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http://www.mdpi.com/1420-3049/20/1/1176

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