Infection-Induced Resistance to Experimental Cerebral Malaria Is Dependent Upon Secreted Antibody-Mediated Inhibition of Pathogenic CD8+ T Cell Responses

Infection-Induced Resistance to Experimental Cerebral Malaria Is Dependent Upon Secreted Antibody-Mediated Inhibition of Pathogenic CD8+ T Cell Responses

Cerebral malaria (CM) is one of the most severe complications of Plasmodium falciparum infection. There is evidence that repeated parasite exposure promotes resistance against CM. However, the immunological basis of this infection-induced resistance remains poorly understood. Here, utilizing the Pla...

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Bibliographic Details
Main Authors: Tovah N. Shaw, Colette A. Inkson, Ana Villegas-Mendez, David J. Pattinson, Patrick Strangward, Kathryn J. Else, Simon J. Draper, Leo A. H. Zeef, Kevin N. Couper
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
cerebral malaria
T cells
B cells
spleen
brain
antibody
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00248/full

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