Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA

Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA

Deregulation of pre-mRNA splicing is observed in many cancers and hematological malignancies. Genes encoding splicing factors are frequently mutated in myelodysplastic syndromes, in which <i>SF3B1</i> mutations are the most frequent. SF3B1 is an essential component of the U2 small nuclea...

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Bibliographic Details
Main Authors: Tiffany Bergot, Eric Lippert, Nathalie Douet-Guilbert, Séverine Commet, Laurent Corcos, Delphine G. Bernard
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
sf3b1
splicing alterations
myelodysplastic syndromes
splice switching oligonucleotides
<i>schizosaccharomyces pombe</i>
Online Access:https://www.mdpi.com/2072-6694/12/3/652

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https://www.mdpi.com/2072-6694/12/3/652

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