IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression

IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression

Abstract Background Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associated with better clinical response and increased survival to anti-PD-...

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Bibliographic Details
Main Authors: Alexander Thiem, Sonja Hesbacher, Hermann Kneitz, Teresa di Primio, Markus V. Heppt, Heike M. Hermanns, Matthias Goebeler, Svenja Meierjohann, Roland Houben, David Schrama
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Melanoma
PD-L1
CD274
p53
TP53
JAK2
Online Access:http://link.springer.com/article/10.1186/s13046-019-1403-9

Internet

http://link.springer.com/article/10.1186/s13046-019-1403-9

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