Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis.

BACKGROUND: The inflammatory response plays a critical role in hypertension-induced cardiac remodeling. We aimed to study how interaction among inflammatory cells causes inflammatory responses in the process of hypertensive cardiac fibrosis. METHODOLOGY/PRINCIPAL FINDINGS: Infusion of angiotensin II...

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Bibliographic Details
Main Authors: Ya-lei Han, Yu-lin Li, Li-xin Jia, Ji-zhong Cheng, Yong-fen Qi, Hong-jia Zhang, Jie Du
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3342394?pdf=render