Spike discharge characteristic of the caudal mesencephalic reticular formation and pedunculopontine nucleus in MPTP-induced primate model of Parkinson disease

The pedunculopontine nucleus (PPN) included in the caudal mesencephalic reticular formation (cMRF) plays a key role in the control of locomotion and wake state. Regarding its involvement in the neurodegenerative process observed in Parkinson disease (PD), deep brain stimulation of the PPN was propos...

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Bibliographic Details
Main Authors: Laurent Goetz, Brigitte Piallat, Manik Bhattacharjee, Hervé Mathieu, Olivier David, Stéphan Chabardès
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118303942