Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women

Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women

Summary: Development of effective prevention and treatment strategies for pre-eclampsia is limited by the lack of accurate methods for identification of at-risk pregnancies. We performed small RNA sequencing (RNA-seq) of maternal serum extracellular RNAs (exRNAs) to discover and verify microRNAs (mi...

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Main Authors: Srimeenakshi Srinivasan, Ryan Treacy, Tiffany Herrero, Richelle Olsen, Trevor R. Leonardo, Xuan Zhang, Peter DeHoff, Cuong To, Lara G. Poling, Aileen Fernando, Sandra Leon-Garcia, Katharine Knepper, Vy Tran, Morgan Meads, Jennifer Tasarz, Aishwarya Vuppala, Soojin Park, Clara D. Laurent, Tony Bui, Pike See Cheah, Rachael Tabitha Overcash, Gladys A. Ramos, Hilary Roeder, Ionita Ghiran, Mana Parast, Xandra O. Breakefield, Amir J. Lueth, Sharon R. Rust, Max T. Dufford, Angela C. Fox, Durlin E. Hickok, Julja Burchard, J. Jay Boniface, Louise C. Laurent, Kim A. Boggess, George R. Saade, Scott A. Sullivan, Glenn R. Markenson, Jay D. Iams, Dean V. Coonrod, Leonardo M. Pereira, M. Sean Esplin, Larry M. Cousins, Garrett K. Lam, Matthew K. Hoffman
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports Medicine
Subjects:
pre-eclampsia
biomarkers
bivariate
miRNA
extracellular RNA
small RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379120300185

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http://www.sciencedirect.com/science/article/pii/S2666379120300185

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