Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers

Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers

Recent clinical trials of small interfering RNAs (siRNAs) highlight the need for robust delivery technologies that will facilitate the successful application of these therapeutics to humans. Arguably, cell targeting by conjugation to cell-specific ligands provides a viable solution to this problem....

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Bibliographic Details
Main Authors: James O. McNamara, Aloysius J. Klingelhutz, Luiza I. Hernandez, Frank J. Hernandez, Katie S. Flenker, Paloma H. Giangrande
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Pharmaceuticals
Subjects:
RNA aptamers
targeted delivery
siRNA delivery
cell-SELEX
cell-internalizing aptamers
Online Access:http://www.mdpi.com/1424-8247/6/3/295

Internet

http://www.mdpi.com/1424-8247/6/3/295

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