NOD Scid Gamma Mice Are Permissive to Allogeneic HSC Transplantation without Prior Conditioning

NOD Scid Gamma Mice Are Permissive to Allogeneic HSC Transplantation without Prior Conditioning

Scid hematopoietic stem cells (HSCs) have an intrinsic defect in their maintenance within the bone marrow (BM) niche which facilitates HSC transplantation without the absolute requirement of prior conditioning. Nevertheless, NOD scid mice have a significantly altered life span due to early developme...

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Bibliographic Details
Main Authors: Tom Verbiest, Rosemary Finnon, Natalie Brown, Paul Finnon, Simon Bouffler, Christophe Badie
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
hematopoietic stem cells
transplantation
NOD scid gamma (NSG)
engraftment
hematopoietic niche occupancy defect
Online Access:http://www.mdpi.com/1422-0067/17/11/1850

Internet

http://www.mdpi.com/1422-0067/17/11/1850

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