l-Citrulline Metabolism in Mice Augments CD4+ T Cell Proliferation and Cytokine Production In Vitro, and Accumulation in the Mycobacteria-Infected Lung

l-Citrulline Metabolism in Mice Augments CD4+ T Cell Proliferation and Cytokine Production In Vitro, and Accumulation in the Mycobacteria-Infected Lung

Activation, recruitment, and effector function of T lymphocytes are essential for control of mycobacterial infection. These processes are tightly regulated in T cells by the availability of l-arginine within the microenvironment. In turn, mycobacterial infection dampens T cell responsiveness through...

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Bibliographic Details
Main Authors: Shannon M. Lange, Melanie C. McKell, Stephanie M. Schmidt, Austin P. Hossfeld, Vandana Chaturvedi, Jeremy M. Kinder, Jaclyn W. McAlees, Ian P. Lewkowich, Sing Sing Way, Joanne Turner, Joseph E. Qualls
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
l-citrulline
l-arginine
T cells
argininosuccinate synthase
argininosuccinate lyase
arginase
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01561/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01561/full

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