Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel.

Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel.

Ca(2+)-loaded calmodulin normally inhibits multiple Ca(2+)-channels upon dangerous elevation of intracellular Ca(2+) and protects cells from Ca(2+)-cytotoxicity, so blocking of calmodulin should theoretically lead to uncontrolled elevation of intracellular Ca(2+). Paradoxically, classical anti-psych...

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Bibliographic Details
Main Authors: Zoltán Oláh, Katalin Jósvay, László Pecze, Tamás Letoha, Norbert Babai, Dénes Budai, Ferenc Otvös, Sándor Szalma, Csaba Vizler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1890308?pdf=render

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http://europepmc.org/articles/PMC1890308?pdf=render

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