Accurate In-Vivo Quantification of CD19 CAR-T Cells after Treatment with Axicabtagene Ciloleucel (Axi-Cel) and Tisagenlecleucel (Tisa-Cel) Using Digital PCR

Accurate In-Vivo Quantification of CD19 CAR-T Cells after Treatment with Axicabtagene Ciloleucel (Axi-Cel) and Tisagenlecleucel (Tisa-Cel) Using Digital PCR

Immunotherapy with CD19-specific chimeric antigen receptor (CAR-) T cells has shown excellent efficacy in relapsed/refractory B-cell cancers. The in vivo expansion and persistence of CAR-T cells after infusion are important response- and toxicity-determining variables, but diagnostic tools are large...

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Bibliographic Details
Main Authors: Anita Badbaran, Carolina Berger, Kristoffer Riecken, Anne Kruchen, Maria Geffken, Ingo Müller, Nicolaus Kröger, Francis A. Ayuk, Boris Fehse
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
tisagenlecleucel (tisa-cel, Kymriah)
axicabtagene ciloleucel (axi-cel, Yescarta)
digital PCR
CAR-T cell monitoring
CAR-T cell persistence
Online Access:https://www.mdpi.com/2072-6694/12/7/1970

Internet

https://www.mdpi.com/2072-6694/12/7/1970

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