Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties

Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties

BackgroundThe secreted glycoprotein Slit2, previously known as an axon guidance cue, has recently been found to protect tissues in pathological conditions; however, it is unknown whether Slit2 functions in cardiac ischemia–reperfusion (IR) injury.MethodsLangendorff-perfused isolated hearts from Slit...

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Bibliographic Details
Main Authors: Xiang Li, Shuang Zheng, Weijiang Tan, Hongqi Chen, Xiaohui Li, Jian Wu, Ting Luo, Xuecong Ren, W. Glen Pyle, Lijing Wang, Peter H. Backx, Ren Huang, Feng Hua Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
ischemia-reperfusion injury
contractile function
RNA sequencing
myofilament phosphorylation
inflammatory response
cTnI
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00228/full

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https://www.frontiersin.org/article/10.3389/fphys.2020.00228/full

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