Impairment of oligodendroglia maturation leads to aberrantly increased cortical glutamate and anxiety-like behaviors in juvenile mice

Impairment of oligodendroglia maturation leads to aberrantly increased cortical glutamate and anxiety-like behaviors in juvenile mice

Adolescence is the critical time for developing proper oligodendro (OL)-neuron interaction and the peak of onset for many cognitive diseases, among which anxiety disorders display the highest prevalence. However, whether impairment of de novo OL development causes neuronal abnormalities and contrib...

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Bibliographic Details
Main Authors: Xianjun eChen, Weiguo ezhang, Tao eLi, Yu eGuo, Yanping eTian, Shubao eLiu, Fei eWang, Haiying eShen, Yue eFeng, Lan eXiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Glutamate
oligodendrocyte
Brain Development
Anxiety behavior
Olig2 knockout
ortical neurons
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00467/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00467/full

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