Modeling of atrophy size trajectories: variable transformation, prediction and age-of-onset estimation

Modeling of atrophy size trajectories: variable transformation, prediction and age-of-onset estimation

Abstract Background To model the progression of geographic atrophy (GA) in patients with age-related macular degeneration (AMD) by building a suitable statistical regression model for GA size measurements obtained from fundus autofluorescence imaging. Methods Based on theoretical considerations, we...

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Bibliographic Details
Main Authors: Charlotte Behning, Monika Fleckenstein, Maximilian Pfau, Christine Adrion, Lukas Goerdt, Moritz Lindner, Steffen Schmitz-Valckenberg, Frank G Holz, Matthias Schmid
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Medical Research Methodology
Subjects:
Geographic atrophy
Age-related macular degeneration
Box-Cox transformation
Mixed-effects models
Prediction
Age-of-onset estimation
Online Access:https://doi.org/10.1186/s12874-021-01356-0

Internet

https://doi.org/10.1186/s12874-021-01356-0

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