Identification of multiple novel protein biomarkers shed by human serous ovarian tumors into the blood of immunocompromised mice and verified in patient sera.

Identification of multiple novel protein biomarkers shed by human serous ovarian tumors into the blood of immunocompromised mice and verified in patient sera.

The most cancer-specific biomarkers in blood are likely to be proteins shed directly by the tumor rather than less specific inflammatory or other host responses. The use of xenograft mouse models together with in-depth proteome analysis for identification of human proteins in the mouse blood is an u...

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Bibliographic Details
Main Authors: Lynn A Beer, Huan Wang, Hsin-Yao Tang, Zhijun Cao, Tony Chang-Wong, Janos L Tanyi, Rugang Zhang, Qin Liu, David W Speicher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3609810?pdf=render

Internet

http://europepmc.org/articles/PMC3609810?pdf=render

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