Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity.

Magnesium (Mg2+) is essential for enzymatic activity, brain function and muscle contraction. Blood Mg2+ concentrations are tightly regulated between 0.7 and 1.1 mM by Mg2+ (re)absorption in kidney and intestine. The apical entry of Mg2+ in (re)absorbing epithelial cells is mediated by the transient...

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Main Authors: Maxime G Blanchard, Jeroen H F de Baaij, Sjoerd A J Verkaart, Anke L Lameris, Christine Basmadjian, Qian Zhao, Laurent Désaubry, René J M Bindels, Joost G J Hoenderop
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4361557?pdf=render