<i>In Vitro</i> and <i>In Silico</i> Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors

<i>In Vitro</i> and <i>In Silico</i> Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors

Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1<i>H</i>-indol-3-yl)methyl)-1,3,4-oxadiazol-2-yl)thio]-<i>N</i>-(thiazol/benzothiazol-2-yl)acetamides (<b>2a–i</b...

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Bibliographic Details
Main Authors: Belgin Sever, Mehlika Dilek Altıntop, Ahmet Özdemir, Gülşen Akalın Çiftçi, Doha E. Ellakwa, Hiroshi Tateishi, Mohamed O. Radwan, Mahmoud A. A. Ibrahim, Masami Otsuka, Mikako Fujita, Halil I. Ciftci, Taha F. S. Ali
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
EGFR
COX-2
cancer
indole
oxadiazole
thiazole
Online Access:https://www.mdpi.com/1420-3049/25/21/5190

Internet

https://www.mdpi.com/1420-3049/25/21/5190

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