Genomic profiling of solid tumors harboring BRD4-NUT and response to immune checkpoint inhibitors

Genomic profiling of solid tumors harboring BRD4-NUT and response to immune checkpoint inhibitors

Background: The translocation t(15:19) produces the oncogenic BRD4-NUT fusion which is pathognomonic for NUT carcinoma (NC), which is a rare, but extremely aggressive solid tumor. Comprehensive genomic profiling (CGP) by hybrid-capture based next generation sequencing of 186+ genes of a cohort of ad...

Full description

Bibliographic Details
Main Authors: Jonathan W. Riess, Shaila Rahman, Waleed Kian, Claire Edgerly, Andreas M. Heilmann, Russell Madison, Shakti H. Ramkissoon, Shai Shlomi Klaitman, Jon H. Chung, Sally E. Trabucco, Dexter X. Jin, Brian M. Alexander, Samuel J. Klempner, Lee A. Albacker, Garrett M. Frampton, Laila C. Roisman, Vincent A. Miller, Jeffrey S. Ross, Alexa B. Schrock, Jeffrey P. Gregg, Nir Peled, Ethan S. Sokol, Siraj M. Ali
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Translational Oncology
Subjects:
NUT midline carcinoma
NUT carcinoma
BRD4-NUT
Checkpoint inhibitor
PD-L1
BRD4
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001765

Internet

http://www.sciencedirect.com/science/article/pii/S1936523321001765

Similar Items