Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria.

Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria.

Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within indiv...

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Main Authors: Zalak Shah, Myo T Naung, Kara A Moser, Matthew Adams, Andrea G Buchwald, Ankit Dwivedi, Amed Ouattara, Karl B Seydel, Don P Mathanga, Alyssa E Barry, David Serre, Miriam K Laufer, Joana C Silva, Shannon Takala-Harrison
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009576

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https://doi.org/10.1371/journal.pgen.1009576

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