Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice

Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice

Abstract Background Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to bone metabolism, its role in OA remains unknown. We therefore investig...

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Bibliographic Details
Main Authors: Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Masayoshi Ishida, Katsumi Okumoto, Osamu Matsuo, Masao Akagi, Hiroshi Kaji
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteoarthritis
Osteoclast
Ovariectomy
Plasminogen activator inhibitor-1
Subchondral bone
Online Access:http://link.springer.com/article/10.1186/s12891-017-1752-5

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http://link.springer.com/article/10.1186/s12891-017-1752-5

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