Nearest-Neighbor Projected Distance Regression for Epistasis Detection in GWAS With Population Structure Correction

Nearest-Neighbor Projected Distance Regression for Epistasis Detection in GWAS With Population Structure Correction

Nearest-neighbor Projected-Distance Regression (NPDR) is a feature selection technique that uses nearest-neighbors in high dimensional data to detect complex multivariate effects including epistasis. NPDR uses a regression formalism that allows statistical significance testing and efficient control...

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Bibliographic Details
Main Authors: Marziyeh Arabnejad, Courtney G. Montgomery, Patrick M. Gaffney, Brett A. McKinney
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Genetics
Subjects:
epistasis
feature selection
GWAS
machine learning
nearest-neighbors
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00784/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00784/full

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