Thalidomide with blockade of co-stimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts

Thalidomide with blockade of co-stimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts

Abstract Background Miscellaneous memory cell populations that exist before organ transplantation are crucial barriers to transplantation. In the present study, we used a skin-primed heart transplantation model in mouse to evaluate the abilities of Thalidomide (TD), alone or in combination with co-s...

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Bibliographic Details
Main Authors: Maoshu Zhu, Yunhan Ma, Kai Tan, Liyi Zhang, Zhaowei Wang, Yongsheng Li, Yingyu Chen, Junjun Guo, Guoliang Yan, Zhongquan Qi
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Immunology
Subjects:
Thalidomide
Co-stimulatory molecule
Monoclonal antibody
Cardiac allograft
Alloantigen
Memory T cell
Online Access:http://link.springer.com/article/10.1186/s12865-020-00352-1

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http://link.springer.com/article/10.1186/s12865-020-00352-1

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