Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys

Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys

Background: Progressive neuronal death in monoaminergic nuclei and widespread accumulation of α-synuclein are neuropathological hallmarks of Parkinson's disease (PD). Given that α-synuclein may be an early mediator of the pathological cascade that ultimately leads to neurodegeneration, decrease...

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Bibliographic Details
Main Authors: Diana Alarcón-Arís, Rubén Pavia-Collado, Lluis Miquel-Rio, Valentín Coppola-Segovia, Albert Ferrés-Coy, Esther Ruiz-Bronchal, Mireia Galofré, Verónica Paz, Leticia Campa, Raquel Revilla, Andrés Montefeltro, Jeffrey H. Kordower, Miquel Vila, Francesc Artigas, Analia Bortolozzi
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:EBioMedicine
Subjects:
α-Synuclein
Antisense oligonucleotide
Axonal neurodegeneration
Dopamine neurotransmission
Mouse and monkey models
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303200

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http://www.sciencedirect.com/science/article/pii/S2352396420303200

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