MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors.

MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors.

MYC and phosphoinositide 3-kinase (PI3K)-pathway deregulation are common in human prostate cancer. Through examination of 194 human prostate tumors, we observed statistically significant co-occurrence of MYC amplification and PI3K-pathway alteration, raising the possibility that these two lesions co...

Full description

Bibliographic Details
Main Authors: Nicola J Clegg, Suzana S Couto, John Wongvipat, Haley Hieronymus, Brett S Carver, Barry S Taylor, Katharine Ellwood-Yen, William L Gerald, Chris Sander, Charles L Sawyers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3048873?pdf=render

Internet

http://europepmc.org/articles/PMC3048873?pdf=render

Similar Items