Oxaliplatin-Induced Neuropathy: Genetic and Epigenetic Profile to Better Understand How to Ameliorate This Side Effect

Oxaliplatin-Induced Neuropathy: Genetic and Epigenetic Profile to Better Understand How to Ameliorate This Side Effect

In the most recent decades, oxaliplatin has been used as a chemotherapeutic agent for colorectal cancer and other malignancies as well. Oxaliplatin interferes with tumor growth predominantly exerting its action in DNA synthesis inhibition by the formation of DNA-platinum adducts that, in turn, leads...

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Bibliographic Details
Main Authors: Jacopo Junio Valerio Branca, Donatello Carrino, Massimo Gulisano, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Alessandra Pacini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
oxaliplatin
neuropathic pain
glial cells
genetic mechanisms
epigenetic mechanisms
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.643824/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.643824/full

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