Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury

Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury

Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with limited available interventions. Host iron acquisition by pathogens and systemic inflammatory response are key events in the pathogenesis of sepsis. In sepsis, hepcidin induces iron sequestration to limit iron avai...

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Bibliographic Details
Main Authors: Yogesh Scindia, Ewa Wlazlo, Joseph Leeds, Valentina Loi, Jonathan Ledesma, Sylvia Cechova, Elizabeth Ghias, Sundararaman Swaminathan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
acute kidney injury
endotoxemia
sepsis
spleen
macrophage
hepcidin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00615/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00615/full

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