Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [18F]Fluspidine—A New Tracer in Clinical Translation for Imaging of σ1 Receptors

Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [18F]Fluspidine—A New Tracer in Clinical Translation for Imaging of σ1 Receptors

The enantiomers of [18F]fluspidine, recently developed for imaging of σ1 receptors, possess distinct pharmacokinetics facilitating their use in different clinical settings. To support their translational potential, we estimated the human radiation dose of (S)-(−)-[18F]fluspidine and (R)-(+)-[18F]flu...

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Bibliographic Details
Main Authors: Mathias Kranz, Bernhard Sattler, Nathanael Wüst, Winnie Deuther-Conrad, Marianne Patt, Philipp M. Meyer, Steffen Fischer, Cornelius K. Donat, Bernhard Wünsch, Swen Hesse, Jörg Steinbach, Peter Brust, Osama Sabri
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Molecules
Subjects:
image based internal dosimetry
[18F]fluspidine
preclinical hybrid PET/MRI
radiation safety
σ1 receptors
Online Access:http://www.mdpi.com/1420-3049/21/9/1164

Internet

http://www.mdpi.com/1420-3049/21/9/1164

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