Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid

Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid

Propionic acid (PPA) is a ubiquitous short-chain fatty acid which is a fermentation product of the enteric microbiome and present or added to many foods. While PPA has beneficial effects, it is also associated with human disorders, including autism spectrum disorders (ASDs). We previously demonstrat...

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Bibliographic Details
Main Authors: Richard E. Frye, Bistra Nankova, Sudeepa Bhattacharyya, Shannon Rose, Sirish C. Bennuri, Derrick F. MacFabe
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
mitochondrial disease
autism
propionic acid
short-chain fatty acids
microbiome
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01670/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01670/full

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