Mechanical load regulates bone growth via periosteal Osteocrin

Mechanical load regulates bone growth via periosteal Osteocrin

Summary: Mechanical stimuli including loading after birth promote bone growth. However, little is known about how mechanical force triggers biochemical signals to regulate bone growth. Here, we identified a periosteal-osteoblast-derived secretory peptide, Osteocrin (OSTN), as a mechanotransducer inv...

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Bibliographic Details
Main Authors: Haruko Watanabe-Takano, Hiroki Ochi, Ayano Chiba, Ayaka Matsuo, Yugo Kanai, Shigetomo Fukuhara, Naoki Ito, Keisuke Sako, Takahiro Miyazaki, Kazuki Tainaka, Ichiro Harada, Shingo Sato, Yasuhiro Sawada, Naoto Minamino, Shu Takeda, Hiroki R. Ueda, Akihiro Yasoda, Naoki Mochizuki
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
Osteocrin
Bone growth
Periosteum
CNP
Chondrocyte
Osteoblast
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007786

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http://www.sciencedirect.com/science/article/pii/S2211124721007786

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