Mechanical load regulates bone growth via periosteal Osteocrin
Summary: Mechanical stimuli including loading after birth promote bone growth. However, little is known about how mechanical force triggers biochemical signals to regulate bone growth. Here, we identified a periosteal-osteoblast-derived secretory peptide, Osteocrin (OSTN), as a mechanotransducer inv...
Main Authors: | Haruko Watanabe-Takano, Hiroki Ochi, Ayano Chiba, Ayaka Matsuo, Yugo Kanai, Shigetomo Fukuhara, Naoki Ito, Keisuke Sako, Takahiro Miyazaki, Kazuki Tainaka, Ichiro Harada, Shingo Sato, Yasuhiro Sawada, Naoto Minamino, Shu Takeda, Hiroki R. Ueda, Akihiro Yasoda, Naoki Mochizuki |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-07-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124721007786 |
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