Metformin attenuates hepatic insulin resistance in type-2 diabetic rats through PI3K/Akt/GLUT-4 signalling independent to bicuculline-sensitive GABAA receptor stimulation

Metformin attenuates hepatic insulin resistance in type-2 diabetic rats through PI3K/Akt/GLUT-4 signalling independent to bicuculline-sensitive GABAA receptor stimulation

Context: Metformin attenuates type-2 diabetes mellitus (T2DM)-induced hepatic dysfunction and altered PI3K/Akt/GLUT-4 signalling in experimental studies. However, its effect on bicuculline-sensitive gamma amino butyric acid (GABA)-A receptor (GABAAR)-mediated calcium-dependent PI3K/Akt/GLUT-4 signal...

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Bibliographic Details
Main Authors: Debapriya Garabadu, Sairam Krishnamurthy
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Pharmaceutical Biology
Subjects:
calcium
glucose transporter-4
liver
nicotinamide
phosphoinositide3-kinase (pi3k)/phosphokinase-b (akt)
streptozotocin
wortmannin
Online Access:http://dx.doi.org/10.1080/13880209.2016.1268635

Internet

http://dx.doi.org/10.1080/13880209.2016.1268635

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