Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma

Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma

Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators of MM-associated bone disease by inhibiting the osteogenic differentiation of human mesenchymal stem cells (hMSCs). Here, we in...

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Bibliographic Details
Main Authors: Stefania Raimondo, Ornella Urzì, Alice Conigliaro, Giosuè Lo Bosco, Sofia Parisi, Melania Carlisi, Sergio Siragusa, Lavinia Raimondi, Angela De Luca, Gianluca Giavaresi, Riccardo Alessandro
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
extracellular vesicles (evs)
exosomes
multiple myeloma (mm)
bone disease
micrornas
osteogenic differentiation
transcription factor sp1.
Online Access:https://www.mdpi.com/2072-6694/12/2/449

Internet

https://www.mdpi.com/2072-6694/12/2/449

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