Microwave Assisted Synthesis of 4-Phenylquinazolin-2(1H)-one Derivatives that Inhibit Vasopressor Tonus in Rat Thoracic Aorta

Microwave Assisted Synthesis of 4-Phenylquinazolin-2(1H)-one Derivatives that Inhibit Vasopressor Tonus in Rat Thoracic Aorta

Quinazolinones have pharmacological effects on vascular reactivity through different mechanisms. We synthesized 4-phenylquinazolin-2(1H)-one derivatives under microwave irradiation and tested them on the rat thoracic aorta. The prepared compounds <b>2a&#8722;2f</b> were obtained in a...

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Bibliographic Details
Main Authors: Rafaela Teixeira, Talita Menengat, Gabriel Andrade, Bruno Cotrim, Cristiano Ponte, Wilson C. Santos, Gabriel Resende
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
microwave irradiation
4-phenylquinazolin-2(1h)-one
vasorelaxation
endothelium
rat thoracic aorta
Online Access:https://www.mdpi.com/1420-3049/25/6/1467

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https://www.mdpi.com/1420-3049/25/6/1467

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