Endoplasmic Reticulum Stress PERK-ATF4-CHOP Pathway Is Associated with Hypothalamic Neuronal Injury in Different Durations of Stress in Rats

Endoplasmic Reticulum Stress PERK-ATF4-CHOP Pathway Is Associated with Hypothalamic Neuronal Injury in Different Durations of Stress in Rats

The hypothalamus, which is the initial part of the hypothalamic-pituitary-adrenal (HPA) axis, plays a critical role in regulating stress in the central nervous system. The present study aimed to determine whether endoplasmic reticulum stress in hypothalamic neurons is differentially stimulated by va...

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Bibliographic Details
Main Authors: Shanyong Yi, Weibo Shi, He Wang, Chunling Ma, Xiaojing Zhang, Songjun Wang, Bin Cong, Yingmin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-03-01
Series:Frontiers in Neuroscience
Subjects:
hypothalamus
HPA axis
glucocorticoid
stress
PERK-ATF4-CHOP pathway
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00152/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00152/full

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