Automated Scale Reduction of Nonlinear QSP Models With an Illustrative Application to a Bone Biology System
Integrating quantitative systems pharmacology (QSP) into pharmacokinetics/pharmacodynamics (PKPD) has resulted in models that are highly complex and often not amenable to further exploration via estimation or design. Because QSP models are usually depicted using nonlinear differential equations it i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-09-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.12324 |