Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresse...

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Bibliographic Details
Main Authors: Svitlana Tyekucheva, Michaela Bowden, Clyde Bango, Francesca Giunchi, Ying Huang, Chensheng Zhou, Arrigo Bondi, Rosina Lis, Mieke Van Hemelrijck, Ove Andrén, Sven-Olof Andersson, R. William Watson, Stephen Pennington, Stephen P. Finn, Neil E. Martin, Meir J. Stampfer, Giovanni Parmigiani, Kathryn L. Penney, Michelangelo Fiorentino, Lorelei A. Mucci, Massimo Loda
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00460-4

Internet

https://doi.org/10.1038/s41467-017-00460-4

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